▎ 摘　　要

In this research, an effective, selective and accurate method for determining the isoniazid (INH) residues is presented based on screen printed carbon electrode (SPCE) modified with graphene oxide/gold nanourchin/layer molecular imprinted polymer. The morphological properties of the suggested sensor were explored by FESEM, FTIR, EDX techniques as well as its electrochemical characteristics versus isoniazid were invigilated in detail. The proposed sensor was capable of measuring the isoniazid in the linear range of 2.5-850.0 nM with a detection limit of 0.85 nM. One of the excellent features of this sensor is its good selectivity to INH in the presence of anionic species from these families of drugs. This sensor has an acceptable price, speed, detection limit, selectivity, reproducibility and fast response time compared to other isoniazid quantification sensors. The proposed sensor was used to measure the INH values in biological samples such as blood and urine with appropriate recovery percentage.