▎ 摘　　要

A multifunctional targeted drug delivery platform (CDHA-MGO) has been successfully constructed by grafting -cyclodextrin-hyaluronic acid polymers (CDHA) to Fe3O4-graphene oxide (MGO). The obtained CDHA-MGO nanocomposite has good water-dispersibility, easy magnetic separation, high near-infrared (NIR) photothermal heating, and excellent biocompatibility. The -cyclodextrin-hyaluronic acid polymers efficaciously enhance the doxorubicin (DOX) loading amount up to 485.43 mgg(-1). Meanwhile, the Fe3O4-graphene oxide provides a facile photothermal response mechanism to handle the NIR-triggered release of DOX in weak acidic solvent environments. Significantly, the DOX-loaded nanocomposite (DOX@CDHA-MGO) has displayed CD44 receptor-mediated active targeting recognition and chemo-photothermal synergistic therapy of hepatoma cells. These findings suggest that the as-prepared drug delivery platform would be of valuable potential for cancer-targeted photo-chemotherapy.