▎ 摘　　要

A new and sensitive voltammetric sensor for palmatine, based on an electrochemically reduced L-methionine functionalized graphene oxide modified glassy carbon electrode (L-Met-ERGO/GCE), is reported. The electrochemical characteristics of palmatine at the proposed sensor were studied systematically and some dynamic parameters were calculated for the first time. A reasonable reaction mechanism for palmatine on the L-Met-ERGO/GCE electrode was proposed and discussed, and this could be a reference for the pharmacological action of palmatine in clinical study. Under optimized conditions, the peak current had a linear relationship with palmatine concentration in the range of 1 x 10(-7) to 5 x 10(-5) mol L-1 with a detection limit of 6 x 10(-8) mol L-1. Additionally, the proposed method was also used to detect palmatine in human urine samples, medicinal tablets and the Chinese herb Fibraurea recisa Pierre with satisfactory results.