▎ 摘　　要

In this paper, a Surface Plasmon Resonance (SPR) biosensor has been numerically developed that used Graphene-MoS2-Au-TiO2-SiO2 hybrid structure for the detection of formalin. This developed sensor has been sensed the presence the formalin based on attenuated total reflection (ATR) method by observing the change of surface plasmon resonance angle-the change of minimum reflectance attributor and the resonance frequency characteristics (RFC)-maximum transmittance attributor. Chitosan has been used as probe sensing medium to accelerate particular reaction with the formalin. Here, graphene is used as biomolecular recognition element because of its high adsorption ability and optical characteristics which helps to improve sensor sensitivity, MoS2 used for it has larger band gap, high fluroscence quenching ability, higher optical absorption efficiency, TiO2-SiO2 bilayer as the improvement of sensitivity and Gold (Au) as the sharp SPR curve. Numerical results give the impression that the variation of RFC and SPR angle for improper sensing of formalin is quiet negligible that confirms no formalin is detected whereas for proper sensing these change are considerably countable that confirms the detection of formalin. From the sensor sensitivity analysis, owing to add TiO2-SiO2 bilayer with Graphene-MoS2 Hybrid layer, maximum sensitivity of 85.375% has been numerically resulted. This high sensor performance is for taking advantages of Graphene surface high selectively which detect bio molecular compounds through pi-stacking force, larger work function (5.1eV) of MoS2 which allows the high sensitive detection of bio targets and Rich plasmon happens at the TiO2-SiO2 interface.