▎ 摘　　要

The difference among different kinds of phospholipids in biomembrane not only lies in different structures in polar head groups, but also in different alkyl chain structures which lead to different phase states. Phase state of phospholipids plays an important role in cell activities. In this study, phospholipid membranes with different phase states were constructed by using two phospholipids with different phase transition temperatures and adjusting their mixing ratio, to reveal the effect of the phase behavior of the phospholipid membrane on the interaction between graphene oxide and the phospholipid membrane. Results showed that, for the extraction of phospholipid from membrane , graphene oxide exhibited significant phase selectivity , and it selectively extracted phospholipids in fluid phase. More importantly, the extraction effect of graphene oxide on fluid-phase phospholipids was affected by the presence of gel-phase phospholipids in the membrane. The extraction could occur only when the fluid-phase phospholipid molecules accounted for the majority of the phospholipids in the membrane, and only the phospholipids in fluid phase were extracted. Therefore, the extraction effect of graphene oxide on phospholipids in membrane not only had fluid-phase selectivity, but also was regulated by the phase behavior of phospholipid membrane.