• 文献标题:   Effects of graphene layer addition on sensitivity of surface plasmon resonance sensor for immunoglobulin M detection
  • 文献类型:   Article
  • 作  者:   PHAN QH, DINH QT, CHEN HM, LIEN CH, PHAM TTH
  • 作者关键词:   immunoglobulin g, surface plasmon resonance, graphene
  • 出版物名称:   OPTICS LASERS IN ENGINEERING
  • ISSN:   0143-8166 EI 1873-0302
  • 通讯作者地址:  
  • 被引频次:   0
  • DOI:   10.1016/j.optlaseng.2023.107657 EA MAY 2023
  • 出版年:   2023

▎ 摘  要

A novel technique is proposed for detecting immunoglobulin M (IgM) using differential Mueller matrix polarimetry and a surface plasmon resonance (SPR) sensor enhanced through the addition of multiple (1-10) thin layers of graphene on the sensing surface. Simulations are first performed to optimize the structure of the SPR device. The feasibility of the proposed sensor is then demonstrated by measuring the principal fast axis angle (alpha) of linear birefringence (LB) of human IgM serum aqueous solution samples with known concentrations in the range of 0-250 ng/ml. The results shows that alpha increases linearly over the considered concentration range. However, alpha reduces with an increasing number of graphene layers. The finest resolution of 7.8 ng/ml is obtained from the sensor incorporating three graphene layers.