▎ 摘　　要

In this work, an innovative drug delivery system based on cyclic RGD-modified (as the targeting agent) and doxorubicin-loaded graphene quantum dots (R-GQDs@DOX) was fabricated for chemo-photothermal combination therapy. These tasks include drug loading capacity, photothermal efficiency, cellular uptake and combination therapeutic effect of R-GQDs@DOX. The structure of R-GQDs@DOX was characterized by FT-IR spectrum, UV-vis spectrum and AFM. The results indicated that the doxorubicin (DOX) could be loaded onto graphene quantum dots (GQDs) via van der Waals interaction (pi-pi stacking) and the drug loading capacity was 96.6 % (wt). The R-GQDs@DOX not only showed obvious pH-responsive release of DOX, but also exhibited great photothermal efficacy for cancer cells. The fluorescence intensity indicated that R-GQDs@DOX was effectively taken up by SK-mel-5 and H460 cells. The combination of chemotherapy and photothermal therapy could more effectively inhibit growth of tumor cells, compared to photothermal therapy or chemotherapy alone.