• 文献标题:   Polyaniline Functionalized Graphene Nanoelectrodes for the Regeneration of PC12 Cells via Electrical Stimulation
  • 文献类型:   Article
  • 作  者:   ZHENG Z, HUANG LB, YAN L, YUAN F, WANG LF, WANG K, LAWSON T, LIN MM, LIU Y
  • 作者关键词:   polyaniline, graphene, neuroregeneration, pc12 cell, electrical stimulation
  • 出版物名称:   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
  • ISSN:  
  • 通讯作者地址:   Wenzhou Med Univ
  • 被引频次:   5
  • DOI:   10.3390/ijms20082013
  • 出版年:   2019

▎ 摘  要

The regeneration of neurons is an important goal of neuroscience and clinical medicine. The electrical stimulation of cells is a promising technique to meet this goal. However, its efficiency highly depends on the electrochemical properties of the stimulation electrodes used. This work reports on the preparation and use of a highly electroactive and biocompatible nanoelectrode made from a novel polyaniline functionalized graphene composite. This nanocomposite was prepared using a facile and efficient polymerization-enhanced ball-milling method. It was used to stimulate the growth of PC12 cells under various electrical fields. The enhanced growth of axons and improved wound regeneration of PC12 cells were observed after this treatment, suggesting a promising strategy for neuro traumatology.