▎ 摘　　要

DNA is one of the most programmable molecules available till date and it is immensely important for nanoarchitectonic works. Herein, we investigate the influence of topological constraints of single stranded DNA, which is attached to a graphene sheet, on its ability to hybridize with a complementary strand. These findings are expected to have a profound impact on nanoarchitectonic, bioelectronic and biosensing applications of graphene. (C) 2012 Elsevier B.V. All rights reserved.