• 文献标题:   PEO-PPO-PEO surfactant exfoliated graphene cyclodextrin drug carriers for photoresponsive release
  • 文献类型:   Article
  • 作  者:   QUINN MDJ, WANG T, AL KOBAISI M, CRAIG VSJ, NOTLEY SM
  • 作者关键词:   photothermal, graphene, hydrogel, nearinfrared, 2d, drug release
  • 出版物名称:   MATERIALS CHEMISTRY PHYSICS
  • ISSN:   0254-0584 EI 1879-3312
  • 通讯作者地址:   Australian Natl Univ
  • 被引频次:   2
  • DOI:   10.1016/j.matchemphys.2017.11.012
  • 出版年:   2018

▎ 摘  要

Liquid exfoliated graphene sheets were incorporated within a-cyclodextrin-triblock copolymer supra molecular hydrogels prepared with a range of polyethylene oxide and polypropylene oxide block sizes and ratios allowing control over the release properties. The strong photothermal activity of graphene was employed to externally activate drug release from within the gels using near-infrared (NIR) irradiation. These supramolecular hybrid hydrogels showed thermoreversible changes in viscosity, which is necessary for an injectable, multiple release point drug delivery depot. This hybrid graphene-surfactant-alpha-CD gel system with thermoreversible properties is demonstrated herein to be externally NIR activated to induce controllable drug release. (C) 2017 Elsevier B.V. All rights reserved.