• 文献标题:   Electrochemical sensor based on reduced graphene oxide supported dumbbell-shaped CuCo2O4 for real-time monitoring of H2O2 released from cells
  • 文献类型:   Article
  • 作  者:   JIANG LY, ZHAO YA, ZHAO P, ZHOU SY, JI Z, HUO DQ, ZHONG DD, HOU CJ
  • 作者关键词:   cuco2o4, reduced graphene oxide, hydrogen peroxide, cell, electrochemical sensor
  • 出版物名称:   MICROCHEMICAL JOURNAL
  • ISSN:   0026-265X EI 1095-9149
  • 通讯作者地址:  
  • 被引频次:   19
  • DOI:   10.1016/j.microc.2020.105521
  • 出版年:   2021

▎ 摘  要

Real-time monitoring of hydrogen peroxide (H2O2) released from living tumor cells is still a huge challenge. Herein, reduced graphene oxide supported dumbbell-shaped CuCo2O4 (CuCo2O4/rGO) was prepared via a facile hydrothermal procedure and an annealing treatment. The CuCo2O4/rGO possess intrinsic peroxidase-like activity, while the 3D dumbbell-shaped sructure consisting of 2D nanosheet layers with large surface area and high conductivity can efficiently enhance electrocatalytic performance of the composites. The CuCo2O4/rGO modified glassy carbon electrode (CuCo2O4/rGO/GCE) exhibited good electrocatalytic performances toward H2O2 with a sensitivity about 320.3 mu A mM(-1) cm(-2) and a low detection limit of 80 nM in a linear range of 30-5010 mu M. Furthermore, the CuCo2O4/rGO/GCE electrochemical sensor was successfully used for real-time detection of H2O2 released from living cells, indicating the potential application of CuCo2O4/rGO in monitoring the critical pathological process in living cells.