• 文献标题:   Graphene oxide: a convenient metal-free carbocatalyst for facilitating amidation of esters with amines
  • 文献类型:   Article
  • 作  者:   PATEL KPP, GAYAKWAD EM, SHANKARLING GS
  • 作者关键词:  
  • 出版物名称:   NEW JOURNAL OF CHEMISTRY
  • ISSN:   1144-0546 EI 1369-9261
  • 通讯作者地址:   Inst Chem Technol
  • 被引频次:   1
  • DOI:   10.1039/c9nj05283f
  • 出版年:   2020

▎ 摘  要

Herein, we report a graphene oxide (GO) catalyzed condensation of non-activated esters and amines, that can enable diverse amides to be synthesized from abundant ethyl esters forming only volatile alcohol as a by-product. GO accelerates ester to amide conversion in the absence of any additives, unlike other catalysts. A wide range of ester and amine substrates are screened to yield the respective amides in good to excellent yields. The improved catalytic activity can be ascribed to the oxygenated functionalities present on the graphene oxide surface which forms H-bonding with the reactants accelerating the reaction. Improved yields and a wide range of functional group tolerance are some of the important features of the developed protocol.