• 文献标题:   Stochastic microsensors based on modified graphene for pattern recognition of maspin in biological samples
  • 文献类型:   Article
  • 作  者:   STEFANVAN STADEN RI, BOGEA IM, ILIEMIHAI RM, GHEORGHE DC, COROS M, PRUNEANU SM
  • 作者关键词:   graphene, cyclodextrin, maltodextrin, stochastic sensor, maspin
  • 出版物名称:   ANALYTICAL BIOANALYTICAL CHEMISTRY
  • ISSN:   1618-2642 EI 1618-2650
  • 通讯作者地址:  
  • 被引频次:   4
  • DOI:   10.1007/s00216-022-04007-5 EA MAR 2022
  • 出版年:   2022

▎ 摘  要

Maspin is a novel serine protease inhibitor differentially expressed in several types of human cancers. It proved to be a key biomarker in the assessment of gastric cancer. Therefore, we design, characterize, and validate two stochastic microsensors based on graphene co-doped with N and S, and modified with alpha-cyclodextrin and maltodextrin, for the pattern recognition and quantification of maspin in whole blood, gastric tumor tissue, saliva, and urine. While the sensitivities were comparable with magnitude order, the variations were in the wideness of the linear concentration range, when measurements were performed at a pH of 7.40. Very low limits of quantification were recorded at both working pHs: 7.40, and 3.00. High recoveries of maspin in whole blood, gastric tissue tumor, saliva, and urine were also recorded.