▎ 摘　　要

In this communication we present the innovative synthesis of porous graphene (PGN) using silver nanoparticles (AgNPs) etching. The PGN material with large specific area and good biocompatible was used to load on great amount of enzyme, horseradish peroxidase (HRP), to fabricate an amperometric sensor. The constructed electrode displayed good electrocatalytic activity toward H2O2 reduction, and the peak current was 4.8 times as large as that of bare glassy carbon electrode. Moreover, the electrocatalytic mechanism of H2O2 reduction on HRP/PGN/GC electrode was also explored.