▎ 摘　　要

Graphene quantum dots (GQDs) have garnered favorable consideration as an advanced metal-free base material for generating reactive oxygen species (ROS). Recently, it is of great interest to develop new catalytic reactions for the GQDs. However, a rapid and simultaneous generation of large amounts of multiple ROS through GQDs is still challenging. Herein, we firstly prepare N-GQDs (nitrogen-doped GQDs) with abundant irregular structure defects and rich reactive functional groups (C=O, C-O, O--C=O, and C-N) in a mechanochemical method, which can simultaneously generate a large number of ROS including 1O2, similar to O2 similar to, and similar to OH in the presence of in the presence of acid (either inorganic or organic acid) without oxygen in dark. At the same time, the N-GQDs were reduced to N-rGQDs (nitrogen-doped reduced GQDs) accompanied by CO2 release. The process and mechanism of ROS generation of the N-GQDs was extensively discussed. The obtained N-GQDs can efficiently catalyze the hydrothermal synthesis of MIL-101, a well-known metal-organic framework, which suggested the N-GQDs can be widely applied in different area to generate ROS.