▎ 摘　　要

A method based on a fiber-optic interferometer to study the pH-dependent interaction between graphene oxide and single-stranded DNA chains is carried out with the assistance of a scanning electron microscope and a confocal laser scanning microscope. The various wavelength shifts of the interferometric fringes of the transmission spectrum reveal the different strengths of interaction between graphene oxide and single-stranded DNA in various pH environments. The present work demonstrates the feasibility of optical fibers for studying the interaction between graphene oxide and biomolecules. It provides a potential means to understand the intermolecular interactions. This technique might effectively supplement the existing tools.