▎ 摘　　要

A novel graphene/zinc nanoflowers nano-composite modified glassy carbon electrode (GR/ZnOnFs/GCE) based electrochemical transducer system has been developed for the sensitive voltammetric analysis of a muscle relaxant drug febuxostat (FEB) in methyl alcohol at pH 6.5 Britton Robinson (BR) buffer. The developed GR/ZnOnFs/GCE) sensor was characterized by microscopic, spectroscopic and electrochemical techniques to get significant information about the morphology, composition and sensing performance of the developed electrode towards reduction of FEB. Various kinetic parameters affecting the monitored electrocatalytic response were evaluated. SWV studies shows linear response between increasing concentrations of FEB (10-400 ng mL(-1)) and cathodic current with correlation coefficient (r(2)) of 0.9954 with reproducibility of 3.26%. The sensing utility of proposed sensor was extended to in vitro determination of the drug in pharmaceutical formulation and in waste water with an acceptable recovery and reproducibility. The fabricated (GR/ZnOnFs/GCE) sensor holds great promise for simple and sensitive quantification of febuxostat using electroanalytical techniques.