▎ 摘　　要

A novel electrochemical sensing platform based on CeO2-Au nanofibers (CeO2-AuNFs) and graphene oxide nanosheets (GO) is proposed for highly sensitive determination of amlodipine (AML) in aqueous media. The CeO2-Au hybrid nanofibers were prepared by the electrospinning technique and then annealed in air. The electrospun CeO2-AuNFs and GO were characterized by different techniques such as transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy-dispersive X-ray analysis (EDS), and Fourier transform infrared spectroscopy (FT-IR). The CeO2-AuNFs/GO-modified glassy carbon electrode) CeO2-AuNFs/GO/GCE (displayed excellent electrochemical catalytic activity toward the oxidation of amlodipine. Using differential pulse voltammetry (DPV), the prepared sensor showed good sensitivity for determining AML in two linear ranges of 0.01-10 and 10-1000 mu mol L-1, with a detection limit of 2.5 nmol L-1. Electrochemical studies indicated that the CeO2-AuNFs/GO/GCE provided a synergistic augmentation on the voltammetric behavior of the electrochemical oxidation of AML. The proposed sensor was successfully applied for the determination of AML in human blood serum, plasma, and pharmaceutical samples with excellent recoveries and without the interferences of coexisting substances.