▎ 摘　　要

Simple, fast, and sensitive detection methods are required for reduced glutathione (GSH), a metabolic substance that acts as an indicator for a variety of diseases and is also found in numerous supplements and drugs. Herein, a sensitive and selective photoelectrochemical (PEC) sensor was developed for GSH detection. The novel PEC sensor was fabricated using CoFe2O4 nanoporous spheres and copper tetraaminophthalocyanine-graphene oxide (CuTAPc-GO) as photoelectric materials. Under illumination, CoFe2O4 facilitated the spatial separation of the photogenerated charge carriers in CuTAPc-GO, thereby enhancing the photocurrent signal of the PEC sensor. The influences of pH, CoFe2O4 amount, coating amount, and applied bias potential on the PEC response toward GSH were investigated. Under optimized conditions, the designed PEC sensor presented a wide linear response range for GSH of 0.25-320 mu M with a detection limit of 0.016 mu M at a signal-to-noise ratio of 3. Moreover, this PEC sensor exhibited excellent selectivity, reproducibility, and stability, showing satisfactory results for the detection of GSH in urine and pharmaceutical drugs.