• 文献标题:   Iron oxide/bismuth oxide nanocomposites coated by graphene quantum dots: "Three-in-one" theranostic agents for simultaneous CT/MR imaging-guided in vitro photothermal therapy
  • 文献类型:   Article
  • 作  者:   BADRIGILAN S, SHAABANI B, GHAREHAGHAJI N, MESBAHI A
  • 作者关键词:   fe/bi, nanotheranostic, xray ct, mri, photothermal therapy, in vitro
  • 出版物名称:   PHOTODIAGNOSIS PHOTODYNAMIC THERAPY
  • ISSN:   1572-1000 EI 1873-1597
  • 通讯作者地址:   Tabriz Univ Med Sci
  • 被引频次:   11
  • DOI:   10.1016/j.pdpdt.2018.10.021
  • 出版年:   2019

▎ 摘  要

Background: The all-in-one nanoprobes (NPs) have drawn biomedical attention in the cancer therapy field due to simultaneously combing the capabilities of therapeutic and diagnostic methods into a single nanoprobe. Method: In this study, we developed a theranostic probe based on superparamagnetic iron oxide (SPIO) and bismuth oxide (Bi2O3) with graphene quantum dots (GQDs) coating to investigate the physical properties for in vitro CT/MR dual-modal biomedical imaging and cancer-specific photothermal therapy (PTT). Result The GQDs-Fe/Bi nanocomposites showed strong light absorbance profile with wide-band in the near-infrared region, without any sharp peak or decline. The highest photo-to-thermal conversion efficacy (n), was found to be 31.8% with the high photostability upon the irradiation of NIR 808-nm laser. The results of in vitro photothermal ablation of cancerous cells demonstrated that the cells significantly killed in the presence of NPs (-53.4%) with a dose-dependent manner in comparison to only laser group (3.0%). In GQDs-Fe/Bi nanocomposites, Bi with a high atomic number (Z = 83) exhibited a superior X-ray attenuation capability (175%) than the clinical CT agent-used dotarem, also, SPIO with excellent magnetization property showed strong T-2-relaxation shortening capability (r(2) = 62.34 mM(-1).s(-1)) as a contrast agent for CT/MR imaging. Conclusion: Our results demonstrate that the developed NPs can incorporate dual-modality imaging capability into a photo absorber for CT/MR imaging-guided tumor PIT.