• 文献标题:   Interactions Between Graphene-Based Materials and Biological Surfaces: A Review of Underlying Molecular Mechanisms
  • 文献类型:   Review
  • 作  者:   CHEN YY, PANDIT S, RAHIMI S, MIJAKOVIC I
  • 作者关键词:   antibacterial activity, biological membrane, cancer therapy, cytotoxicity, graphene derivative, molecular mechanism
  • 出版物名称:   ADVANCED MATERIALS INTERFACES
  • ISSN:   2196-7350
  • 通讯作者地址:  
  • 被引频次:   10
  • DOI:   10.1002/admi.202101132 EA NOV 2021
  • 出版年:   2021

▎ 摘  要

Understanding the underlying molecular mechanism of how graphene materials (GMs) interact with biological surfaces is the key to develop safe and effective biomedical applications of GMs. Here, a systematic and comprehensive mechanistic perspective of interactions between pristine GMs and biological membranes is provided. To this end, first the known mechanisms of interaction between GMs and membrane components are summarized and classified, with a focus on phospholipids, cholesterol, and membrane proteins. Both experimental observations and computational simulations are included. Detailed experimental conditions and physiochemical properties of GMs are listed for each cited application. At the end of this review, current challenges and conflicts that limit biomedical applications of GMs are discussed. Based on reported mechanisms, guidelines for future studies to address the remaining challenges are proposed, specifically with respect to modulating the intrinsic properties of GMs for more efficient and safer therapeutic applications.