▎ 摘　　要

Recently, graphene has been applied to modify biomaterials due to excellent physicochemical property and biocompatibility. However, some problems still exist especially the weak binding force between graphene and other biomaterials. Herein, a promising platform with photothermal property was constructed by fabricating the adhesive graphene in situ on the surface of beta-tricalcium phosphate (beta-Ca-3(PO4)(2), beta-TCP) bioceramics using chemical vapor deposition (CVD). The result of ultrasonic cleaning treatment of graphene modified beta-TCP (G-TCP) demonstrated that the prepared graphene coating could firmly modified on beta-TCP due to the occurrence of carbothermal reduction on the ceramic surface to promote the nucleation and growth of graphene. G-TCP composites exhibited excellent photothermal effects when irradiated with 808 nm near-infrared laser (NIR). The photothermal effect of G-TCP composites could induce more than 90% of osteosarcoma cell (MNNG) death in vitro. These results confirmed that the graphene could be successfully fabricated in situ on the surface of beta-TCP by CVD method, and exhibited high firmness and excellent photothermal performance, revealing a promising application in the photothermal therapy of bone tumors. (C) 2020 Elsevier Ltd. All rights reserved.