▎ 摘　　要

An innovative electrochemical sensing platform was fabricated for the simultaneous determination of paracetamol (PCT) and naproxen sodium (NPX). The glassy carbon electrode (GCE) was modified with a hybrid porous nanocomposite of carboxylated nanocellulose (CNCS), nitrogen doped graphene (NDG) and an anionic surfactant sodium dodecyl sulfate (SDS) by simple ultrasonication and drop-casting method. The (CNCS-NDG)-SDS nanocomposite showed high electrocatalytic performance towards the redox reaction of PCT and the oxidation of NPX between 0.2 V and 0.9 V at 0.1 V s- 1 with broad linear ranges from 0.01 to 90 mu M and 0.1 to 60 mu M for PCT and NPX, respectively. The limit of detection is 0.0015 mu M and 0.0018 mu M for PCT and NPX, respectively, while the limit of quantification is 0.015 mu M and 0.018 mu M, respectively. The (CNCS-NDG)-SDS/GCE sensor showed good stability, reproducibility and repeatability for the electrochemical determination of PCT and NPX.