▎ 摘　　要

A new electrochemical sensor constructed using reduced graphene oxide/Ti-based metal-organic framework (RGO/Ti-MOF)-modified glassy carbon electrode (GCE) has been introduced for electro-catalytic oxidation and determination of Propranolol, a most used beta-adrenergic receptor. Synthesized RGO/Ti-MOF composite as a synergistic catalyst has very active sites and great ability for electron transfer to oxidized Propranolol in phosphate buffer solution (PBS, pH 7). The oxidation over-potential of Propranolol decreased significantly, and its peak currents increased greatly at the modified electrode (GCE/RGO/Ti-MOF). The synthesized GO and Ti-MOF were identified by various methods. The calibration curve of Propranolol was linear in the range of 0.01-10 mu M, and the detection limit was 0.008 mu M. Finally, the electrochemical sensor was used for the quantification of Propranolol in tablet and urine samples.