• 文献标题:   Spontaneous ssDNA stretching on graphene and hexagonal boron nitride in plane heterostructures
  • 文献类型:   Article
  • 作  者:   LUAN BQ, ZHOU RH
  • 作者关键词:  
  • 出版物名称:   NATURE COMMUNICATIONS
  • ISSN:   2041-1723
  • 通讯作者地址:   IBM Thomas J Watson Res
  • 被引频次:   3
  • DOI:   10.1038/s41467-019-12584-w
  • 出版年:   2019

▎ 摘  要

Single-stranded DNA (ssDNA) molecules in solution typically form coiled structures, therefore stretching ssDNA is extremely crucial before applying any nanotechnology for ssDNA analysis. Recent advances in material fabrication enable the deployment of nano-channels to manipulate, stretch, sort and map double-stranded DNA (dsDNA) molecules, however nanochannels fail to stretch ssDNA molecules due to the ultra-short persistence length and the potential nonspecific-interaction-induced clogging. Given the significance of ssDNA stretching in genome analysis, here we report an ssDNA stretching platform: two dimensional in-plane heterostructure comprising graphene and hexagonal boron nitride (h-BN), and show that ssDNA can be stretched on a h-BN nanostripe sandwiched between two adjacent graphene domains ("nanochannel"). We further show that with a biasing voltage the stretched ssDNA can be electrophoretically transported along the "nanochannel", allowing easy controls/manipulations. When being conveniently integrated with existing atomic resolution sensors, the heterostructure platform paves the way for sequencing DNA on a planar surface.