▎ 摘　　要

This article presents an SPR biosensor (Structure: SF10 prism-Au-ZnO-Graphene-PBS solution) to sense DNA hybridization using angular interrogation method at an operating wavelength of 633 nm. Its performance parameters, i.e., sensitivity (S), detection accuracy (DA), and figure of merit (FoM) are evaluated for different values of graphene's chemical potential at room temperature. Sensitivity (141.9 degrees/RIU), DA (0.64 Degree(-1)) and FoM (9.14 RIU-1) are achieved for the proposed SPR biosensor at 0 eV chemical potential of graphene at the room temperature. The maximum sensitivity of 156.33 degrees/RIU is obtained for the proposed SPR biosensor at 1.25 eV graphene's chemical potential. The present article utilizes biocompatibility, chemical stability, and unique electrical and optical properties of both graphene and ZnO in SPR sensor for DNA hybridization.