▎ 摘　　要

Partially reduced grphene oxide (pRGO) is synthesized using a mild reduction method by incubating GO suspension under alkaline condition at room tempeature. Aptamer(AS1411) non. covalent bind. ing with cardiogreen(ICG), a photosensitizer and photothermal effect molecule, to the surface of pRGO, was used to target cancer cells for photodynamic therapy(PDT) and photothermal therapy(PTT). Structure and morphology of the as. synthesized pRGO and pRGO-AS1411-ICG(pRAI) nanocomposites were confirmed by menas of FTIR, Raman, XPS, UV. Vis, transmission electron microscopy(TEM) and energy dispersive spec. trometer(EDS). pRAI targets cancer cells with AS1411 to produce singlet oxygen for PDT and photothermal effect for PTT upon near. infrared(NIR) light irradiation. Since pRGO is decorated with several AS1411-ICG molecules, the pRGO-AS1411-ICG conjugate yields enhanced binding and therapeutic effect by the added ability to carry multiple photosensitizers. Consequently, pRAI offers a remarkably improved and synergistic therapeutic effect on cells.