▎ 摘　　要

In this paper, Fe304/Mn02 doped graphene molecularly imprinted hybrid material (Fe,04/MnO2MIP@ RGO) was successfully synthesized via reversible addition fragmentation chain transfer (RAFT) molecularly imprinting technique by using methacrylic acid as functional monomer, divinylbenzene as cross linker, Fe304/Mn02 @ RGO as carrier, and 173-estradiol (173-E2) as template molecule. A novel molecularly imprinting electrochemical sensor by using Fe304/Mn02-MIP @ RGO modified electrode was constructed to specifically detect trace 173-E2 in water. The experimental results showed that the Fe3 04/ Mn02-MIP@ RGO electrochemical sensor exhibited rapid and linear current response to 17P -E2 in water samples with a linear range of 4 nmol/L to 0. 8 timol/L (R =0. 9852), the detection limit was 47. 2 pmol/L (30-) and the relative standard deviation (RSD) was from 2. 1% to 2. 5%. This study provides a simple and efficient, economical and reliable method for the monitoring of 173-estradiol in the complex water environment.