▎ 摘　　要

Herein, a kind of novel hemin-based metal organic frameworks (Fe-hemin-MOFs) with unique peroxidase-like bioactivity was developed for the first time. The synthesized Fe-hemin-MOFs exhibited satisfactory catalytic activity toward hydrogen peroxide (H2O2). When it was further supported on Chitosan-reduced graphene oxide (CS-rGO), amplified electrochemical signal could be obtained. The Fe-hemin-MOFs/CS-rGO composite was used to construct a novel H2O2 electrochemical sensor. The elec-trocatalytic reduction of H2O2 displayed two segments linearity range from 1 to 61 mM and 61-1311 mM, as well as a low detection limit of 0.57 mM. Furthermore, the proposed sensor was successfully used for real-time monitoring of H2O2 released from living cells, which extended the practical application of MOFs-based sensors in monitoring the pathological process in living cells. (C) 2020 Elsevier B.V. All rights reserved.