• 文献标题:   Graphene nanoparticles as pseudostationary phase for the electrokinetic separation of nonsteroidal anti-inflammatory drugs
  • 文献类型:   Article
  • 作  者:   BENITEZMARTINEZ S, SIMONET BM, VALCARCEL M
  • 作者关键词:   capillary electrophoresi, graphene, nonsteroidal antiinflammatory drug, pseudostationary phase
  • 出版物名称:   ELECTROPHORESIS
  • ISSN:   0173-0835 EI 1522-2683
  • 通讯作者地址:   Univ Cordoba
  • 被引频次:   8
  • DOI:   10.1002/elps.201300130
  • 出版年:   2013

▎ 摘  要

The exceptional properties of graphene (G) were exploited here to facilitate capillary electrokinetic separations. Two types of commercially available G consisting of nanoparticles containingone to three andfour to six G sheets, respectively, were compared for this purpose. Both proved effective in separating the arylpropyl derivatives of nonsteroidal anti-inflammatory drugs. The highest resolution and shortest migration times were obtained with G containing high amount of single and double G nanosheets. G affords higher resolution than other types of nanoparticles; stable suspensions can be easily prepared and used as BGE without the need of adding an additional surfactant. This results in a high reproducibility in migration times and stability in background noise. The LOD and LOQ obtained by using G nanoparticles as pseudostationary phases spanned the range 0.29-1.18 mg/L and 0.95-3.95 mg/L, respectively, and the RSD was less than 4.7% in all instances.