• 文献标题:   Prolonged Suppression of Neuropathic Pain by Sequential Delivery of Lidocaine and Thalidomide Drugs Using PEGylated Graphene Oxide
  • 文献类型:   Article
  • 作  者:   SONG TY, GU KF, WANG WL, WANG H, YANG YL, YANG LJ, MA PX, MA XJ, ZHAO JH, YAN RY, GUAN J, WANG CP, QI Y, YA J
  • 作者关键词:   cell culture, cell biology, cns, drug interaction, facilitated diffusion, transport, in vitro model, biomaterial, controlled release, delivery, drug transport, nanotechnology
  • 出版物名称:   JOURNAL OF PHARMACEUTICAL SCIENCES
  • ISSN:   0022-3549 EI 1520-6017
  • 通讯作者地址:   First Hosp Shijiazhuang
  • 被引频次:   3
  • DOI:   10.1002/jps.24598
  • 出版年:   2015

▎ 摘  要

The management of patients with neuropathic pain is challenging. Monotherapy with a single pain relief drug may encounter different difficulties, such as short duration of efficacy and hence too many times of drug administration, and inadequate drug delivery. Recently, nanocarrier-based drug delivery systems have been proved to provide promising strategies for efficient drug loading, delivery, and release. In the present study, we developed poly(ethylene glycol) methyl ether functionalized graphene oxide (GO) bearing two commonly used drugs of lidocaine (LDC) and thalidomide (THD) as an agent for the treatment of neuropathic pain. The sequential drug release of LDC and THD from the developed LDC-THD-GO nanosheets exhibited a synergistic effect on neuropathic pain in vitro and in vivo, as evidenced by the increased pain threshold in mechanical allodynia and hyperalgesic response tests, and the improved inhibition of proinflammatory cytokines TNF-, IL-1, IL-6, and nitric oxide. We believed that the present study herein would hold promise for future development of a new generation of potent agents for neuropathic pain relief. (c) 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:3851-3860, 2015