▎ 摘　　要

In this paper, a novel, "green", efficient and atom-economical methodology for the synthesis ofN-(alkyl)-2-phenylimidazo[1,2-a]pyridin-3-amine derivatives based on copper catalyzed oxidative cyclization is presented. An efficient copper nanocatalyst was fabricated by immobilization of Cu on beta-Cyclodextrin (beta CD)functionalized magnetic graphene oxide nanosheets (denoted as Cu@beta CD@MGO). This catalyst primarily oxidizes benzylic alcohols to aldehydes by aerobic O-2. The obtained aldehydes, in situ, takes part in a three component reaction with pyridin-2-amine and isocyanides to produce correspondingN-(alkyl)-2-phenylimidazo[1,2-a]pyridin-3-amine derivatives. The catalyst was characterized by TEM, SEM, VSM, FT-IR, XRD, TGA and ICP. As an advantage, the catalyst showed to be highly recoverable and no appreciable leaching was observed after 10 runs.