• 文献标题:   Synthesis and Drug-Delivery Behavior of Chitosan-Functionalized Graphene Oxide Hybrid Nanosheets
  • 文献类型:   Article
  • 作  者:   RANA VK, CHOI MC, KONG JY, KIM GY, KIM MJ, KIM SH, MISHRA S, SINGH RP, HA CS
  • 作者关键词:   biocompatibility, chitosan, drug delivery system, functionalization of polymer, solution propertie
  • 出版物名称:   MACROMOLECULAR MATERIALS ENGINEERING
  • ISSN:   1438-7492 EI 1439-2054
  • 通讯作者地址:   Pusan Natl Univ
  • 被引频次:   225
  • DOI:   10.1002/mame.201000307
  • 出版年:   2011

▎ 摘  要

Chitosan-functionalized graphene oxides (FGOCs) were successfully synthesized. FGOCs were found to significantly improve the solubility of the GO in aqueous acidic media. The presence of organic groups was confirmed by means of XPS and TGA. Restoration of the sp(2) carbon network and exfoliation of graphene sheets were confirmed by Raman spectroscopy, UV-visible spectroscopy and WAXD. The SEM and AFM investigations of the resultant FGOCs showed that most of the graphene sheets were individual and few were layered. Controlled release behavior of Ibuprofen and 5-fluorouracil was then investigated. We found that FGOCs are a promising new material for biological and medical applications.