▎ 摘　　要

A novel electrochemical sensing platform based on composite material was prepared, consisting of molec-ularly imprinted polymer coated on graphene oxide (MIP-GO), for the selective and sensitive analysis of amoxicillin (AMOX). Amoxicillin (AMOX) is a newer version of penicillin which belongs to the beta-lactam family. The monitoring of AMOX in food as well as in environment plays a crucial role in public health protection. Through Hummer's method, GO was prepared from graphite powder which was modified into its acid derivative by treating with 4-amino benzoic acid. It further undergoes surface modification with allyl bromide to form vinylated GO-O-CH2-CH = CH2. The polymerization process was carried out using methacrylic acid (MAA) as the monomer and ethylene glycol (EGDMA) as cross-linker, azobisisobutyroni-trile (AIBN) as the initiator and AMOX as template molecule. The different preparatory stages of materials were characterized by using Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffractometer (XRD), and Scanning Electron Microscope (SEM). The detection limit of the present work is 10 -10 M shows that prepared material is suitable for the detection of AMOX in deca-level concentrations. In addition to that GO-MIP based sensors exhibit excellent electrocatalytic performance in linear to the concentrations of AMOX with high selectivity in comparison with several other methods and it shows linearity from 10 -7 to 10 -10 M concentrations. Interference study was carried out using 1.0 mu M solution of cephalexin, ampi-cillin and cloxacillin as well as AMOX. The optimum pH for the sensing of AMOX is pH 8.0 and GO-MIP sensor shows a good result, is due to the momentous sensitizing effect of material and increases electron transfer and surface area for big loading of GO-MIP (c) 2023 Published by Elsevier B.V.