▎ 摘　　要

The environmental responsiveness of smart responsive gels under specific conditions has attracted great attention in recent years. In this paper, we have investigated the preparation of previously unreported electric field/temperature-sensitive three-dimensional graphene oxide hydrogels and their transdermal absorption studies, choosing indapamide (IND) as a model drug. Three-dimensional graphene oxide (3D@GO) has a unique three-dimensional network-like structure, excellent electrical properties, and mechanical properties. Three-dimensional graphene oxide network structures were prepared based on graphene oxide (GO) with the addition of formaldehyde, resorcinol, and sodium carbonate as reactants and catalysts. 3D@GO was compounded with a temperature-sensitive gel matrix, hydroxybutyl chitosan (HBC), to obtain a temperature-sensitive composite hydrogel with enhanced mechanical, electrical, and thermal properties. After applying 3D@GO-HBC to the skin, it can rapidly convert from liquid to semi-solid and adhere to the skin at the skin temperature. It can also be used as a carrier for controlled drug release under electric field conditions. This study of transdermal-controlled release drug delivery under electric field modulation showed that the cumulative release values of IND were 2.02 mu g/cm(2), 2.21 mu g/cm(2), 2.45 mu g/cm(2), 2.85 mu g/cm(2) , and 3.16 mu g/cm(2) in 24 h under the application of electric fields of 0 mu A, 50 mu A, 100 mu A, 150 mu A and 200 mu A, respectively. The results indicated that 3D@GO-HBC hydrogels have good electrical sensitivity and can enhance the cumulative transdermal release of drugs under electric field conditions, providing an advantage not previously reported for controlled release of drugs.