• 文献标题:   Graphene-Based SELDI Probe with Ultrahigh Extraction and Sensitivity for DNA Oligomer
  • 文献类型:   Article
  • 作  者:   TANG LAL, WANG JZ, LOH KP
  • 作者关键词:  
  • 出版物名称:   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
  • ISSN:   0002-7863
  • 通讯作者地址:   Natl Univ Singapore
  • 被引频次:   228
  • DOI:   10.1021/ja104017y
  • 出版年:   2010

▎ 摘  要

We demonstrate that graphene can be used as an ultrahigh efficiency preconcentration and detection platform for ssDNA. DNA-adsorbed graphene can be used directly for Surface Enhanced Laser Desorption Ionization-Time of Flight-Mass Spectrometry (SELDI-TOF-MS). The rapid enrichment of biomolecules and direct, label-free detection are potentially useful for analysis in proteomics and genomics.