▎ 摘　　要

Surface-enhanced Raman spectroscopy is a strong and sensitive analysis tool that can realize single-molecule level detection and provide the fingerprint information of molecules, which has been widely applied in analysing chemistry and biomolecules and monitoring environment. However, it is still a challenge to design and prepare SERS substrates with high enhancement factor, simple synthesis, stability and reproducibility. Here, we synthesized gold clusters anchored on reduced graphene oxide (Au clusters@rGO) using co-reduction method to achieve high SERS enhancement. The substrate of gold clusters anchored on reduced graphene oxide combines the chemical enhancement of reduced graphene oxide and the electromagnetic enhancement of gold clusters, leading to an ultrahigh enhancement factor of 3.5 x 10(7). The efficient SERS was ascribed to the high localized surface plasmon resonance (LSPR) of aggregations of gold clusters, the synergistic effect of gold clusters and reduced graphene oxide, and the charge transfer between graphene and the molecules. This research will provide an invaluable strategy to design and prepare superior -property SERS substrates.