• 文献标题:   Superparamagnetic graphene oxide-Fe3O4 nanoparticles hybrid for controlled targeted drug carriers
  • 文献类型:   Article
  • 作  者:   YANG XY, ZHANG XY, MA YF, HUANG Y, WANG YS, CHEN YS
  • 作者关键词:  
  • 出版物名称:   JOURNAL OF MATERIALS CHEMISTRY
  • ISSN:   0959-9428 EI 1364-5501
  • 通讯作者地址:   Tianjin Med Univ
  • 被引频次:   742
  • DOI:   10.1039/b821416f
  • 出版年:   2009

▎ 摘  要

A superparamagnetic graphene oxide -Fe3O4 nanoparticles hybrid (GO-Fe3O4) was prepared via a simple and effective chemical precipitation method. The amount of loading of Fe3O4 on GO was estimated as 18.6 wt% by atomic absorption spectrometry. The hybrid was then loaded with doxorubicin hydrochloride (DXR) and the loading capacity was as high as 1.08 mg mg(-1). Both of the GO-Fe3O4 hybrids before and after loading with DXR can be dispersed well in aqueous solution. They can congregate under acidic conditions and move regularly under the force of an external magnet. Furthermore, the aggregated hybrid can be redispersed to form a stable suspension under basic conditions. These properties make it a potential candidate for controlled targeted drug delivery and release.