• 文献标题:   Dye-enhanced graphene oxide for photothermal therapy and photoacoustic imaging
  • 文献类型:   Article
  • 作  者:   WANG YW, FU YY, PENG QL, GUO SS, LIU G, LI J, YANG HH, CHEN GN
  • 作者关键词:  
  • 出版物名称:   JOURNAL OF MATERIALS CHEMISTRY B
  • ISSN:   2050-750X EI 2050-7518
  • 通讯作者地址:   Fuzhou Univ
  • 被引频次:   58
  • DOI:   10.1039/c3tb20986e
  • 出版年:   2013

▎ 摘  要

Graphene oxide (GO) has many exciting advantages such as easy preparation, low toxicity, good solubility and stability in aqueous solution. However, GO itself has a low near-infrared (NIR) absorption, and thus is not suitable for photothermal therapy and photoacoustic imaging. To overcome this limitation, a novel dye-enhanced GO is prepared utilizing the pi-pi stacking interactions between GO and indocyanine green (ICG). The ICG-GO complex has a high optical absorbance in the NIR region and exhibits excellent photothermal properties under NIR irradiation. In order to improve the cancer-targeting activity, GO was modified with folic acid (FA). In vitro experiments showed that the ICG-GO-FA nanocomposite could be used for targeted photothermal cancer cell destruction. Moreover, the application of the ICG-GO-FA nanocomposite for photoacoustic imaging was also demonstrated.