• 文献标题:   Graphene oxide-gadolinium (III) oxide nanoparticle composite: a novel MR contrast agent with high longitudinal and transverse relaxivity
  • 文献类型:   Article
  • 作  者:   VENKATESHA N, POOJAR P, GEETHANATH S, SRIVASTAVA C
  • 作者关键词:   mri contrast agent, nanoparticle, graphene oxide, proton relaxivity
  • 出版物名称:   MATERIALS RESEARCH EXPRESS
  • ISSN:   2053-1591
  • 通讯作者地址:   Indian Inst Sci
  • 被引频次:   2
  • DOI:   10.1088/2053-1591/1/4/045008
  • 出版年:   2014

▎ 摘  要

Production of bio-compatible contrast agent materials to enhance the sensitivity of the magnetic resonance imaging (MRI) technique is a highly active area in MRI related research. This work illustrates the potential of a new material: graphene oxide-gadolinium (III) oxide nanoparticle (GO-Gd2O3) composite in yielding both transverse (16.3mM(-1) s(-1)) and longitudinal relaxivity (40mM(-1) s(-1)) values which are significantly higher than the proton relaxivity values achieved using the gadolinium based contrast agents currently used in MRI. Such high proton relaxivity values can facilitate low dosage of GO-Gd2O3 composite for obtaining both T-1 and T-2 weighted high signal-to-noise ratio images in MRI.