▎ 摘　　要

In this work, a graphene quantum dots composite thin film-based surface plasmon resonance (SPR) sensor was developed and experimentally demonstrated for glucose detection. The proposed work incorporates the modification of SPR gold film with carboxyl-functionalized graphene quantum dots-nanocrystalline cellulose (CGQDs-NCC) to improve the detection sensitivity of glucose. The sensing performances of gold/CGQDs-NCC thin film as a function of the sensitivity and binding affinity were analysed. The experimental results show that the linear response of the gold/CGQDs-NCC thin film were 13.296 degrees mu M-1, 0.13983 degrees mu M-1 and 0.00753 degrees mu M-1 for the 0 mu M to 0.03 mu M, 0.03 mu M to 0.5 mu M and 0.5 mu M-10 mu M of glucose concentrations, respectively. The binding affinity has been analyzed using Langmuir and Sips model where it revealed that gold/ CGQDs-NCC thin film has higher affinity constant as compared to unmodified gold film. All in all, this paper gives the idea that the introduction of gold-modified CGQDs-NCC thin film in SPR has good potential for detecting glucose solution.