• 文献标题:   Graphene and carbon nanocompounds: biofunctionalization and applications in tissue engineering
  • 文献类型:   Review
  • 作  者:   JESION I, SKIBNIEWSKI M, SKIBNIEWSKA E, STRUPINSKI W, SZULCDABROWSKA L, KRAJEWSKA A, PASTERNAK I, KOWALCZYK P, PINKOWSKI R
  • 作者关键词:   tissue regeneration, cytotoxicity, biocompatibility, mammalian cell, nanotechnology
  • 出版物名称:   BIOTECHNOLOGY BIOTECHNOLOGICAL EQUIPMENT
  • ISSN:   1310-2818 EI 1314-3530
  • 通讯作者地址:   Warsaw Univ Life Sci
  • 被引频次:   22
  • DOI:   10.1080/13102818.2015.1009726
  • 出版年:   2015

▎ 摘  要

In tissue engineering, the possibility of a comprehensive restoration of the tissue, structure or a portion of the organ is largely determined by the type of material used. A wide range of materials such as graphene and other carbon nanocompounds which have different physical and chemical properties can be expected to react differently upon contact with biomolecules, cells and tissues. This mini-review describes the current knowledge on biocompatibility of graphene and its derivatives with a variety of mammalian cells, such as osteoblasts, neuroendocrine cells, fibroblasts NIH/3T3 line, PMEFs (primary mouse embryonic fibroblasts), stem cells and neurons. The results from different studies give hope for the possibility of graphene to be used in the regeneration of almost all tissues, including neural tissue implants or in the form of neural chips, which may allow in the future treatment of degenerative diseases and injuries of the central nervous system.