▎ 摘　　要

Cerebral cortex plays a crucial role in the functioning of the organism. This study aimed to examine the cerebral cortex cytotoxicity of polyethylene glycol (PEG)-loaded nano-graphene oxide (nGO), called PEGylated-nGO (PEG-nGO). Graphene oxide sheets were synthesised using an improved Hummer's method. The nGO was produced by ultrasonic cracking of these sheets. Biocompatibility of nGO was increased by PEG loading. Cortical cells were then treated with various concentrations of PEG-nGO for 24h. Trypan blue exclusion, MTT, and LD Hassays were used to determine cell viability and cytotoxicity respectively. Cellular uptake was examined by transmission electron microscopy. Together, our findings indicated dose-dependent effect of PEG-nGO. This study thus might contribute to conclusion on the clinical potentials of PEG-nGO.