• 文献标题:   Biofunctionalized Rebar Graphene (f-RG) for Label-Free Detection of Cardiac Marker Troponin I
  • 文献类型:   Article
  • 作  者:   TUTEJA SK, SABHERWAL P, DEEP A, RASTOGI R, PAUL AK, SURI CR
  • 作者关键词:   functionalized rebar graphene, carbon nanotube, biochip, cardiac marker, troponin i, clinical diagnostic
  • 出版物名称:   ACS APPLIED MATERIALS INTERFACES
  • ISSN:   1944-8244 EI 1944-8252
  • 通讯作者地址:   AcSIR Cent Sci Instrument Org
  • 被引频次:   29
  • DOI:   10.1021/am503524e
  • 出版年:   2014

▎ 摘  要

One-step microwave-assisted unscrolling of carbon nanotubes to form functionalized rebar graphene (f-RG) is reported. The well-characterized f-RG on an interdigitated electrode biochip in a FET configuration showed enhanced electronic properties, as demonstrated with I-V characteristics. The developed device was biofunctionalized with specific anti-cTnI antibodies exhibiting a shift of threshold voltage from -2.15 V to -0.5 V and decrease in electron mobility from 3.609 x 10(4) to 8.877 x 10(3) cm(2) V-1 s(-1). The new sensing strategy holds great promise for its applicability in diagnostics exhibiting high sensitivity (similar to 1 pg/mL) and specificity toward cardiac marker (cTnI).