• 文献标题:   Targeted photothermal release of antibiotics by a graphene nanoribbon-based supramolecular glycomaterial
  • 文献类型:   Article
  • 作  者:   SHANG Y, ZHANG S, GAN HQ, YAN KC, XU FG, MAI YY, CHEN DJ, HU XL, ZOU L, JAMES TD, HE XP
  • 作者关键词:  
  • 出版物名称:   CHEMICAL COMMUNICATIONS
  • ISSN:   1359-7345 EI 1364-548X
  • 通讯作者地址:  
  • 被引频次:   0
  • DOI:   10.1039/d2cc05879k EA JAN 2023
  • 出版年:   2023

▎ 摘  要

Here, we report the simple construction of a supramolecular glycomaterial for the targeted delivery of antibiotics to P. aeruginosa in a photothermally-controlled manner. A galactose-pyrene conjugate (Gal-pyr) was developed to self-assemble with graphene nanoribbon-based nanowires via pi-pi stacking to produce a supramolecular glycomaterial, which exhibits a 1250-fold enhanced binding avidity toward a galactose-selective lectin when compared to Gal-pyr. The as-prepared glycomaterial when loaded with an antibiotic that acts as an inhibitor of the bacterial folic acid biosynthetic pathway eradicated P. aeruginosa-derived biofilms under near-infrared light irradiation due to the strong photothermal effect of the nanowires accelerating antibiotic release.