• 文献标题:   Sensitive Voltammetric Sensor for Tryptophan Detection by Using Polyvinylpyrrolidone Functionalized Graphene/GCE
  • 文献类型:   Article
  • 作  者:   HE QG, LIU J, FENG JX, WU YY, TIAN YL, LI GL, CHEN DC
  • 作者关键词:   polyvinylpyrrolidone, graphene, tryptophan, electrochemical behavior, voltammetric determination
  • 出版物名称:   NANOMATERIALS
  • ISSN:  
  • 通讯作者地址:   Foshan Univ
  • 被引频次:   2
  • DOI:   10.3390/nano10010125
  • 出版年:   2020

▎ 摘  要

In this paper, an electrochemical method for the measurement of tryptophan (Trp) was developed based on a glassy carbon electrode modified with polyvinylpyrrolidonefunctionalized graphene (PVP-GR)/glassy carbon electrode (GCE). In 0.1 M phosphate buffer solution (PBS, pH = 2.2), compared with bare GCE, PVP/GCE, and GR/GCE, the oxidation peak current of Trp increased dramatically at PVP-GR/GCE. The oxidation mechanism of Trp on the PVP-GR/GCE was discussed and the experimental conditions were optimized. Under the best experimental conditions, the oxidation peak current of Trp was proportional to its concentration in the range of 0.06 mu M-10.0 mu M and 10.0-100.0 mu M, and the limit of detection (LOD) was 0.01 mu M (S/N = 3). The target modified electrode with excellent repeatability, stability and selectivity, was successfully applied to detectTrp in drugs and biological samples.