• 文献标题:   Highly Efficient One-Pot Three Component Synthesis of 2H-Indazoles by Consecutive Condensation, C-N and N-N Bond Formations Using Cu/Aminoclay/Reduced Graphene Oxide Nanohybrid
  • 文献类型:   Article
  • 作  者:   BEHROUZ S
  • 作者关键词:  
  • 出版物名称:   JOURNAL OF HETEROCYCLIC CHEMISTRY
  • ISSN:   0022-152X EI 1943-5193
  • 通讯作者地址:   Shiraz Univ Technol
  • 被引频次:   3
  • DOI:   10.1002/jhet.2777
  • 出版年:   2017

▎ 摘  要

A simple and straightforward one-pot three-component synthesis of 2H-indazoles through copper-catalyzed consecutive condensation, C-N and N-N bond formations of easily accessible starting materials under ligand-free conditions is described. In this protocol, treatment of substituted 2-bromobenzaldehydes, structurally diverse amines, and [bmim]N-3 in the presence of Cu/aminoclay/reduced graphene oxide nanohybrid (Cu/AC/r-GO nanohybrid) as an efficient heterogeneous catalyst affords the corresponding 2H-indazoles in good to excellent yields. The influence of effective parameters on the efficient progress of the reaction was studied. The Cu/AC/r-GO nanohybrid is a stable and inexpensive catalyst that could be simply prepared, recovered, and reused for several reaction runs with no significant decrease in its reactivity.