• 文献标题:   Graphene quantum dots with nitrogen-doped content dependence for highly efficient dual-modality photodynamic antimicrobial therapy and bioimaging
  • 文献类型:   Article
  • 作  者:   KUO WS, CHEN HH, CHEN SY, CHANG CY, CHEN PC, HOU YI, SHAO YT, KAO HF, HSU CLL, CHEN YC, CHEN SJ, WU SR, WANG JY
  • 作者关键词:   reactive oxygen specie, photodynamic therapy, nitrogendoped graphene quantum dot, antimicrobial, photostability, contrast probe
  • 出版物名称:   BIOMATERIALS
  • ISSN:   0142-9612 EI 1878-5905
  • 通讯作者地址:   Natl Cheng Kung Univ
  • 被引频次:   41
  • DOI:   10.1016/j.biomaterials.2016.12.022
  • 出版年:   2017

▎ 摘  要

Reactive oxygen species is the main contributor to photodynamic therapy. The results of this study show that a nitrogen-doped graphene quantum dot, serving as a photosensitizer, was capable of generating a higher amount of reactive oxygen species than a nitrogen-free graphene quantum dot in photodynamic therapy when photoexcited for only 3 min of 670 nm laser exposure (0.1 W cm(-2)), indicating highly improved antimicrobial effects. In addition, we found that higher nitrogen-bonding compositions of graphene quantum dots more efficiently performed photodynamic therapy actions than did the lower compositions that underwent identical treatments. Furthermore, the intrinsically emitted luminescence from nitrogen-doped graphene quantum dots and high photostability simultaneously enabled it to act as a promising contrast probe for tracking and localizing bacteria in biomedical imaging. Thus, the dual modality of nitrogen-doped graphene quantum dots presents possibilities for future clinical applications, and in particular multidrug resistant bacteria. (C) 2016 Elsevier Ltd. All rights reserved.