▎ 摘　　要

Breast cancer remains the leading cause of morbidity and mortality among women. Therefore, there is an urgent need to develop effective treatments for breast cancer. Peptide-based therapies have been applied to treat various diseases, particularly cancer. Peptides that exhibit antimicrobial properties have recently been found to inactivate a wide range of cancer cells. However, some peptides degrade quickly in biological systems. Therefore, peptide-based nanotherapeutic approaches for cancer have been widely studied but are still in the early stages of research. The objective of this study is to synthesize a nanocomposite, NRC-03 peptide conjugated to polydopamine (pDA)-modified reduced graphene oxide (rGO), to facilitate the use of near-infrared light-activatable photothermal therapy to destroy breast tumor cells. The results show that immobilizing NRC-03 on the surface of dopamine-modified rGO can increase the stability of the NRC-03 peptide in a biological system. Furthermore, a burst release of the NRC-03 from NRC-03-pDA/rGO was observed under photothermal and tumor environment conditions. Overall, the results show that NRC-03-pDA/rGO combines the advantages of NRC-03, dopamine, and rGO, displaying excellent biocompatibility and anticancer properties; thus, it shows strong potential for augmenting photothermal therapy for breast cancer.