▎ 摘　　要

Hydrothermal method is a cheap and green approach for the synthesis of composite powders. In this study, the zirconia (ZrO2)-based nanocomposite powder was reinforced with reduced graphene oxide (ZrO2/RGO) and was synthesized in a one-pot as a precursor for bone scaffold applications. Moreover, for the stimulation of osseointegration in bone scaffolds, Hydroxyapatite (HA) was used in 10 wt%. In this regard, the two types of ZrO2/RGO and ZrO2/RGO/HA precursors were applied for the fabrication of bone scaffolds via 3D printing and finally, the mechanical and biological properties of scaffolds were evaluated. For characterization, the X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FE-SEM), compress strength, and the 3-(4,5-dimethylthiazol2-yl)-2,5-diphenyl-2H-tetrazolium bromide as MTT assay protocol were performed. The results demonstrated that the ZrO2/RGO scaffolds with a tolerance of compressive stress of 240.11 MPa depicted better mechanical properties compared with ZrO2/RGO/HA with the compress strength of 141.66 MPa. Moreover, after 7 days of bone scaffolds immersion in simulated body fluid (SBF) the growth of compressive strength began while after 28 days reached 260.15 MPa for ZrO2/RGO and 192.31 for ZrO2/RGO/HA. Finally, the cellular response of the scaffolds indicated the lack of cellular toxicity of the scaffolds during MTT assay. (c) 2022 The Society of Powder Technology Japan. Published by Elsevier B.V. and The Society of Powder Technology Japan. All rights reserved.